Welcome to the Gilbert Lab! Our goal is to improve skeletal muscle strength in the settings of aging, injury and disease by enlisting the potent regenerative function of stem cells residing in muscle tissue. To achieve this goal it is critical to gain a better understanding of the mechanisms governing muscle satellite cell quiescence, self-renewal, differentiation, and niche occupancy. Our passion is to identify architectural features of the native satellite cell niche that are perturbed in the course of skeletal muscle aging and disease, which we then model in culture to reveal the cellular and molecular impact on muscle stem cell fate. By applying bioengineering principles to muscle stem cell biology and integrating biologists with engineers and computer scientists, we hope to gain a holistic understanding of muscle stem cell regulation by its dynamic microenvironment.